Read e-book online Biologics in General Medicine PDF

By W.-H. Boehncke (Editor), H.H. Radeke (Editor)

This is often the 1st booklet to hide each perspective within the scientific software of biologics. Readers won't in basic terms locate that every one of the biologics at the moment authorized for medical use are delineated in a standardized manner, but in addition the "differential remedy" with biologics in fields together with dermatology and neurology is defined intimately and summarized in therapy algorithms. Shorter sections on biologic biotechnology in addition to security and regulatory concerns supplement the extra clinically-oriented vital chapters.

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In adalimumab OLE studies, patient retention is high, supporting the tolerability data from pivotal trials. Recent evaluations of adalimumab for the treatment of PsA have demonstrated significant efficacy in both skin and joint components of the disease. Results from the PREMIER trial demonstrate that combination therapy with adalimumab plus MTX provided significant inhibition of disease progression as well as significant clinical remission outcomes superior to MTX monotherapy in patients with early, aggressive RA.

2003). The open-label extension of this study is ongoing. Of the patients completing 5 years of treatment, clinical efficacy was sustained, with 76 %, 64 %, and 39 % of patients achieving ACR20, 50, 70 responses; 52 % achieving clinical remission; and 28 % having no physical limitations (Weinblatt et al. 2004, 2005). Furthermore, the majority of these patients were able to reduce corticosteroid and/ or MTX dosages without adversely affecting long-term efficacy (Weinblatt et al. 2005). DE019 was a randomized, double-blind, placebocontrolled, multicenter study assessing the ability of adalimumab to inhibit radiographic progression and reduce disease activity in 619 RA patients with active disease despite therapy with MTX.

1991, 1993). In animal models of inflammatory arthritis, TNF has been shown to accelerate disease activity, and anti-TNF antibodies have been Fig. 2. Tumor necrosis factor (TNF) cascade in rheumatoid arthritis. 2 Pharmacodynamics In patients with RA, a rapid decrease in levels of acute phase reactants of inflammation, C-reactive protein, and fibrinogen, as well as the serum cytokines, IL-1 q and IL-6, and IL-1 receptor antagonist is observed following treatment with adalimumab (Abbott Laboratories; Barrera et al.

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