By N. Hainf
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The nuclear receptors are proteins specific for steroid hormone binding. The cell surface receptors usually are integrated cell membrane proteins consisting of extracellular domain, transmembrane domain, and cytoplasmic domain.
When no lactose is present, binding of the lac repressor protein to a sequence called the lac operator, which overlaps the transcription start site, blocks transcription initiation by the polymerase. When lactose is present, lactose molecules bind to specific binding sites in each subunit of the tetrameric lac repressor, causing a conformational change in the protein that makes it dissociate from the lac operator. As a result, the polymerase binds to promoter to initiate transcription of the lac operon (Fig.
For example, the budding yeast Saccharomyces cerevisiae contain 6000 genes. By using the two-hybrid screening or the double mutation scoring method, a large scale of protein–protein interactions has been mapped. Elucidating the whole set of proteins and the interaction of the proteins in living cells is an important task of systems biology. 3 Polysaccharides Polysaccharides (glycans) are carbohydrate polymers made up of many monosaccharides joined together by glycosidic linkages. The most abundant monosaccharide is Dglucose (dextrose), a six-carbon sugar containing an aldose group and five hydroxyl groups.