By Harold E. Himwich and Williamina A. Himwich (Eds.)
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CHANGES I N BRAIN MONOAMINE LEVELS 17 ENZYME INHIBITORS Selectively acting enzyme inhibitors should belong to the relatively safe tools for studying monoamine functions in the brain. Of course themonoamine oxidase inhibitors have already proved useful. Among these agents nialamide and MO 911 appear to be most selective. They seem to give comparable results. In our laboratory we are mostly using nialamide, which became available first. When these drugs are given to mice in doses sufficient to cause the virtually complete inhibition of monoamine oxidase, the monoamines accumulate rapidly in the brain.
Within these areas they are found close to or in the immediate surroundings of the blood vessels. The latter constitute the so-called primary plexus of the hypophysial portal system. In the mouse (as in most mammals) this plexus is distributed over the whole eminence and the infundibular stem. Thus the fluorescent Rrfcrencrs p . 43/44 40 BENGT FALCK structures are found in that part of the neurohypophysis in which blood vessels are exclusively drained towards the sinus system of the pars distalis of the adenohypophysis via the portal vessels.
Causes but slight sedation and ptosis. A second injection of the same dose 24 h later causes clearcut sedation and ptosis (Anden and Magnusson, unpublished experiments). T h s may be interpreted to mean that the first injection References p . 25-27 24 ARVID CARLSSON causes inhibition of synthesis, but transmitter functions are unimpaired since they may proceed at the expense of the stores. At the time of the second injection, however, the noradrenergic transmitter has been replaced by the less active a-methyl analogue in the store.