New PDF release: Biochemistry - the Molecular Basis of Life

By Trudy McKee, James R. McKee

Biochemistry: The Molecular foundation of Life is a one-semester textual content concentrating on the basic biochemical ideas that underpin the trendy existence sciences. The 6th variation bargains deeper assurance of the chemistry of reactions whereas emphasizing the connection among biochemistry and human biology. Equipping scholars with a whole view of the residing nation, Biochemistry: The Molecular foundation of Life emphasizes challenge fixing and applies biochemical ideas to the fields of future health, agriculture, engineering, and forensics. It moves the proper stability of biology and chemistry insurance, continually putting biochemical ideas into the context of the body structure of the cellphone and biomedical applications.

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Activation barrier (transition state, ‡) Reactants (A) ⌬G‡cat ⌬G‡uncat ⌬G Products (B) Reaction coordinate (A B) FIGURE 1–27 Energy changes during a chemical reaction. An activation barrier, representing the transition state, must be overcome in the conversion of reactants (A) into products (B), even though the products are more stable than the reactants, as indicated by a large, negative free-energy change (⌬G). The energy required to overcome the activation barrier is the activation energy (⌬G‡).

Thus far, the molecular phylogeny derived from gene sequences is consistent with, but in many cases more precise than, the classical phylogeny based on macroscopic structures. Although organisms have continuously diverged at the level of gross anatomy, at the molecular level the basic unity of life is readily apparent; molecular structures and mechanisms are remarkably similar from the simplest to the most complex organisms. These similarities are most easily seen at the level of sequences, either the DNA sequences that encode proteins or the protein sequences themselves.

Theodosius Dobzhansky, The American Biology Teacher, March 1973 ■ Genetic information is encoded in the linear sequence of four deoxyribonucleotides in DNA. Great progress in biochemistry and molecular biology during the decades since Dobzhansky made this striking generalization has amply confirmed its validity. The remarkable similarity of metabolic pathways and gene sequences in organisms across the phyla argues strongly that all modern organisms share a common evolutionary progenitor and were derived from it by a series of small changes (mutations), each of which conferred a selective advantage to some organism in some ecological niche.

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