By Han A. A. van Heugten, Yvonne E. G. Eskildsen-Helmond, Henriette W. de Jonge (auth.), Jos M. J. Lamers, Pieter D. Verdouw (eds.)
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Content material: CONTENTS ; PREFACE ; review ; 1. GALECTINS IN sickness AND power healing ways ; ANATOLE A. KLYOSOV AND PETER G. TRABER ; GALECTIN AND GALECTIN INHIBITORS: STRUCTURAL features ; 2. LOW-MOLECULAR WEIGHT INHIBITORS OF GALECTINS ; HAKON LEFFLER AND ULF J. NILSSON ; three. FROM CARBOHYDRATE TO PEPTIDOMIMETIC INHIBITORS OF GALECTINS ; KEVIN H.
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Pfliigers Arch 422: 198-200, 1992 Clemo HF, Feher JJ, Baumgarten CM: Modulation of rabbit ventricular cell volume and NaiK/2CI cotransport by cGMP and atrial natriuretic factor. J Gen Physiol 100: 89-114, 1992 Molecular and Cellular Biochemistry 157: 31-38, 1996. © 1996 Kluwer Academic Publishers. A. Meij Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas TX 75235-9041, USA Abstract Heterotrimeric GTP-binding and -hydrolyzing proteins (G proteins) link members of a family of seven-helix transmembrane receptors (G protein-coupled receptors, GPCR) to intracellular effectors.
Indeed, a proline-rich, microfilament- and focal adhesion-associated protein termed VASP was shown to be phosphorylated in vivo by both cGK and cAK and may serve as a convergence point for the cAMP and cGMP pathway in platelets [59,60]. The recent identification ofVASP in a variety of other cell types, including cardiomyocytes, where it was found in association with the intercalating discs , and in endothelial cells , suggests a more general role of this protein in cyclic nucleotide-regulated processes.
Changes in phospholipase C-coupled receptor pathways in models of heart disease PLC activity Contractile response Receptor G protein Ref. NE/AII Coronary occlusion rat 1 wk t t 8 wk bas B NE Em" EC 50 B ,l. 1 225 d 250 d t t B V m" All u,Ad Km ,l. ,l. ,l. B B Bm" KD B t B m" KD t t B B t t B t B B ,l. t t t an increase in norepinephrine- and angiotensin II-stimulated PLC activity in isolated cells. The level of G q at this stage was unmodified, whereas an increase in G j could be detected already (Table 2).