By Neal E. Artz, Elizabeth M. Osman
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Extra info for Biochemistry of Glucuronic Acid
Branching and substitution tend to inhibit oxidation and to result in metabolites which are excreted in conjugation with glucuronic acid and can be isolated. Many investigations in the field of aliphatic compounds were reported before quantitative methods for determining glucuronic acid had been developed and, in some cases, before a qualitative method with any degree of specificity was known. Therefore, except in cases where crystalline products were isolated, much of the work needs confirmation.
Phenols Because of their importance in medical science, the metabolism of phe nols has been the subject of numerous investigations. When phenol itself is fed to rabbits, about 90 per cent is excreted as phenylglucuronoside and phenylsulfuric acid (331). Oxidation products account for most of the re maining 10 per cent; only traces of free phenol are excreted. The products of oxidation, catechol, hydroquinone (18) and 1,2,4-benzenetriol, occurring only in small amounts, are excreted as ethereal sulfates (116).
They believed glucuronic acid probably repre sented an intermediate in the metabolism of sugar protected from further oxidation by conjugation. It is now recognized that conjugated glucuronic acid, in small amounts, is a normal constituent of the urine, presumably combined with normal metabolites or toxic substances ingested in the diet. Although normal variation is high, there is ample evidence that administration of substantial doses of compounds which conjugate with glucuronic acid does cause a marked increase in glucuronic acid output.