New PDF release: Biochemistry of Atherosclerosis (Advances in Biochemistry in

By Sukhinder C. Kaur (Editor)

This publication covers many features of atherogenesis, with specific emphasis on lipid and lipoprotein metabolism. It contains all features of the law of ldl cholesterol homeostasis and the significance of every pathway. additionally explored are the jobs of nuclear hormone receptors on lipid and lipoprotein metabolism and their complicated roles in atherogenesis. The publication additional discusses how genetic reports may also help comprehend the complexities that mediate those features of atherogenesis.

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J Biol Chem 272: 15777–15781, 1997. Sakai N, Vaisman BL, Koch CA, Hoyt RF Jr, Meyn SM, Talley GD, Paiz JA, Brewer HB Jr, Santamarina-Fojo S: Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency. J Biol Chem 272: 7506–7510, 1997. Forte T, Nichols A, Glomset J, Norum K: The ultrastructure of plasma lipoproteins in lecithin:cholesterol acyltransferase deficiency. Scand J Clin Lab Invest Suppl 137: 121–132, 1974.

Clinically, despite the disruption of the RCT pathway and the severe low level of HDL-C, CLD subjects are paradoxically not particularly predisposed to premature CHD [10, 16–18]. Instead, there is a high prevalence of glomerulopathy in these subjects [19]. Other phenotypes include modest hypertriglyceridemia (HTG), presence of LpX vesicles and mild anemia [20]. In FED, LCAT activity is absent selectively in the HDL fractions. In these subjects, HDL-C is markedly reduced but cholesterol esterification in the apoB-containing lipoprotein particles is relatively preserved.

Rader DJ: Regulation of reverse cholesterol transport and clinical implications. Am J Cardiol 92(4A): 42J–49J, 2003. 7. Knight BL: ATP-binding cassette transporter A1: regulation of cholesterol efflux. Biochem Soc Trans 32(Pt 1): 124–127, 2004. 8. Zhang Y, Zanotti I, Reilly MP, Glick JM, Rothblat GH, Rader DJ: Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation 108: 661–663, 2003. 9. Nakamura Y, Kotite L, Gan Y, Spencer TA, Fielding CJ, Fielding PE: Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating highdensity lipoprotein with plasma lecithin/cholesterol acyltransferase.

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