By Sukhinder C. Kaur (Editor)
This publication covers many features of atherogenesis, with specific emphasis on lipid and lipoprotein metabolism. It contains all features of the law of ldl cholesterol homeostasis and the significance of every pathway. additionally explored are the jobs of nuclear hormone receptors on lipid and lipoprotein metabolism and their complicated roles in atherogenesis. The publication additional discusses how genetic reports may also help comprehend the complexities that mediate those features of atherogenesis.
Read Online or Download Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease) PDF
Similar biochemistry books
Content material: CONTENTS ; PREFACE ; assessment ; 1. GALECTINS IN sickness AND strength healing techniques ; ANATOLE A. KLYOSOV AND PETER G. TRABER ; GALECTIN AND GALECTIN INHIBITORS: STRUCTURAL points ; 2. LOW-MOLECULAR WEIGHT INHIBITORS OF GALECTINS ; HAKON LEFFLER AND ULF J. NILSSON ; three. FROM CARBOHYDRATE TO PEPTIDOMIMETIC INHIBITORS OF GALECTINS ; KEVIN H.
The avidin-biotin advanced has been used for isolation (affinity chromatography), localization (affinity cytochemistry, mobile cytometry, and blotting technology), and diagnostics (immunoassay, histopathology, and gene probes). lately, utilization of the method has been prolonged to incorporate different components. This quantity covers those new functions and methodologies together with hybridoma know-how, bioaffinity sensors, affinity focusing on, and drug supply, in addition to cross-linking, immobilization, and fusogenic stories
Contemporary Advances in Steroid Biochemistry comprises the court cases of the second one overseas Symposium of the magazine of Steroid Biochemistry. keeping apart 38 papers as chapters, this e-book discusses the partial purification of steroid-receptor complexes; enzymatic strategies in steroid assay; mass fragmentography of steroid hormones; organic results of 18-hydroxylation; and steroidogenesis in adrenal cells.
Additional resources for Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease)
J Biol Chem 272: 15777–15781, 1997. Sakai N, Vaisman BL, Koch CA, Hoyt RF Jr, Meyn SM, Talley GD, Paiz JA, Brewer HB Jr, Santamarina-Fojo S: Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency. J Biol Chem 272: 7506–7510, 1997. Forte T, Nichols A, Glomset J, Norum K: The ultrastructure of plasma lipoproteins in lecithin:cholesterol acyltransferase deficiency. Scand J Clin Lab Invest Suppl 137: 121–132, 1974.
Clinically, despite the disruption of the RCT pathway and the severe low level of HDL-C, CLD subjects are paradoxically not particularly predisposed to premature CHD [10, 16–18]. Instead, there is a high prevalence of glomerulopathy in these subjects . Other phenotypes include modest hypertriglyceridemia (HTG), presence of LpX vesicles and mild anemia . In FED, LCAT activity is absent selectively in the HDL fractions. In these subjects, HDL-C is markedly reduced but cholesterol esterification in the apoB-containing lipoprotein particles is relatively preserved.
Rader DJ: Regulation of reverse cholesterol transport and clinical implications. Am J Cardiol 92(4A): 42J–49J, 2003. 7. Knight BL: ATP-binding cassette transporter A1: regulation of cholesterol efflux. Biochem Soc Trans 32(Pt 1): 124–127, 2004. 8. Zhang Y, Zanotti I, Reilly MP, Glick JM, Rothblat GH, Rader DJ: Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation 108: 661–663, 2003. 9. Nakamura Y, Kotite L, Gan Y, Spencer TA, Fielding CJ, Fielding PE: Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating highdensity lipoprotein with plasma lecithin/cholesterol acyltransferase.