Download e-book for kindle: Behavioral Neurobiology of the Endocannabinoid System by Stephen P. H. Alexander, David A. Kendall (auth.), Dave

By Stephen P. H. Alexander, David A. Kendall (auth.), Dave Kendall, Stephen Alexander (eds.)

The endocannabinoid signalling procedure is without doubt one of the key modulators of vital frightened functionality. This quantity offers well timed and in-depth insurance of the jobs of the endocannabinoid signalling process within the neurobiology of habit. it really is crucial examining for any researcher with a history in neuroscience desirous to recognize extra concerning the endocannabinoids. the 1st part offers a complete account of the part elements of the process (the signalling molecules, artificial and degradative enzymes and receptors), their position in the vital anxious procedure and the endocannabinoids’ roles in neural plasticity. This part additionally describes the toolboxes (genetic and pharmacological) used to review the process. the second one part concentrates on endocannabinoid functionality within the regulate of ordinary physiological behaviors together with a connection with the evolution of the procedure in keeping with its operation in non-mammalian vertebrates. the quantity concludes through addressing the significance of the endocannabinoids in pathological behaviors together with affective and cognitive problems, neurodegenerative stipulations, feeding and drug abuse.

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3 GTPgS Binding as a Measure of GPCR Function . . . . . . . . . . . . . . . . . . 41 CB1 Receptor Gene Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Chromosomal Structure, Potential Alternative Splicing . . . . . . . . . . . . . . . 2 CNR1 Polymorphisms . . . . . . . . . . . . . . . . . . . . . . . . . . . .

38 Receptor Pharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 GPCR Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Radioligand Binding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 GTPgS Binding as a Measure of GPCR Function . .

3 GTPgS Binding as a Measure of GPCR Function . . . . . . . . . . . . . . . . . . 41 CB1 Receptor Gene Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Chromosomal Structure, Potential Alternative Splicing . . . . . . . . . . . . . . . 2 CNR1 Polymorphisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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