Download e-book for iPad: Antibodies, Antigens, and Molecular Mimicry by John J. Langone (Eds.)

By John J. Langone (Eds.)

The severely acclaimed laboratory typical, Methods in Enzymology, is likely one of the so much hugely revered guides within the box of biochemistry. because 1955, every one quantity has been eagerly awaited, usually consulted, and praised by way of researchers and reviewers alike. The sequence comprises a lot fabric nonetheless correct at the present time - actually a necessary book for researchers in all fields of existence sciences

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Disappearance of the antireceptor antibodies in the serum coincided with appearance of adrenergic ligand-binding activity, corresponding to the development of the autologous anti-anti-idiotypic antibodies (Ab3) directed against the induced anti-idiotypic molecules. The results of Couraud indicate that the rapid and cyclic disappearance of antireceptor antibodies (Ab2) is due to effects mediated by anti-idiotypic antibodies directed against Ab2. It was shown that a fraction of these anti-anti-idiotypic antibodies (Ab3) were able to bind alprenolol, the original antigen, and therefore could be considered as "Ab l-like" antibodies.

Rev. 90, 29 (1986). 134T. Kieber-Emmons, E. Getzoff, and H. K6hler, Int. Reo. lmmunol. 2, 339 (1987). 135 p. M. Coleman, G. M. Air, R. G. Webster, J. N. Vargehese, A. T. Baker, M. R. Leutz, P. A. Tullock, and W. G. Laver, Immunol. Today 8, 323 (1987). ~36C. Bruck, M. S. Co, M. Slaoui, G. N. Gaulton, T. Smith, B. N. Fields, J. I. Mullins, and M. I. Greene, Proc. Natl. Acad. Sci. A. 83, 6578 (1986). m G. Mazza, P. Oilier, G. Somm6, D. Moinier, J. Rocca-Serra, J. Van Rietschoten, J. Th~ze, and M. Fougereau, Ann.

Vauquelin, and A. D. Strosberg, Biochem. Pharmacol. 27, 1527 (1978). 26 IDIOTYPES, ANTI-IDIOTYPES, AND MOLECULAR MIMICRY [1] alprenolol, a potent adrenergic antagonist, in rabbits. The antialprenolol antibodies were capable of binding to other antagonists and had less avidity to catecholamine agonists. They then raised anti-idiotypic antibodies in rabbits by immunizing with antialprenolol immunoglobulins. These anti-idiotypic antibodies bound specifically to turkey erythrocytes, which possess/31-AR.

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